Updating on the pathogenesis of systemic lupus erythematosus Chatbisesual

This suggests that genetic factors play an important role in the predisposition of the disease.However, most cases of SLE are sporadic without identifiable genetic predisposing factors, suggesting that multiple environmental or yet unknown factors may also be responsible.Among other MHC gene systems, inherited complement deficiencies also influence disease susceptibility.

updating on the pathogenesis of systemic lupus erythematosus-78

In addition, patients with Klinefelter’s syndrome, characterised by hypergonadotrophic hypogonadism, are prone to the development of SLE.

These observations suggest a role for endogenous sex hormones in disease predisposition.

Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of antibodies to components of the cell nucleus in association with a diverse array of clinical manifestations.

The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. SLE shows a strong familial aggregation, with a much higher frequency among first degree relatives of patients.

However, in most cases, consistent results could not be obtained in subsequent studies in different ethnic groups.

Some of these polymorphic genes may confer risk to certain subsets of patients with SLE.The loss of immune tolerance, increased antigenic load, excess T cell help, defective B cell suppression, and the shifting of T helper 1 (Th1) to Th2 immune responses leads to B cell hyperactivity and the production of pathogenic autoantibodies.Finally, certain environmental factors are probably required to trigger the disease.An association of HLA DR2 and DR3 with SLE is a common finding in patients of different ethnicities, with a relative risk for the development of disease of approximately two to five.The HLA class II genes have also been associated with the presence of certain autoantibodies such as anti-Sm (small nuclear ribonuclear protein), anti-Ro, anti-La, anti-n RNP (nuclear ribonuclear protein), and anti-DNA antibodies.Moreover, in extended families, SLE may coexist with other organ specific autoimmune diseases such as haemolytic anaemia, immune thrombocytopenic purpura, and thyroiditis.

Tags: , ,