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Erythrocyte sedimentation rate (ESR) was measured by the Westergren method, ranging from 0 to 140 mm/h.

C-reactive protein (CRP) was measured by phy Cardio Phase hs CRP nephelometry (Dade Behring, Deerfield, Illinois, USA) with a lowest detectable limit of 0.15 mg/l [].

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Hand BMD was measured by digital X-ray radiogrammetry (DXR) based on hand and wrist radiographs obtained at baseline and 1, 2 and 5-year follow-up.

During the study period, DXR-BMD decreased by median (inter quartile range) 1.7% (4.1 to 0.4), 2.8% (5.3 to 0.9) and 5.6% (11.7 to 2.3) after 1, 2 and 5 years, respectively.

As part of the EURIDISS (European Research on Incapacitating Disease and Social Support) study, a Norwegian arm of the cohort was followed longitudinally.

At inclusion in 1992, 238 patients aged from 20 to 70 years, with a clinical diagnosis of RA and disease duration of less than four years were included [].

This article focuses on 163 patients who had radiographs taken at baseline and after one, two or five years follow-up.

Of the 163 patients in this study, 128 had X-rays at all four time points, 29 at three time points and six patients at two time points.The coefficient of variation was found to be 0.28%, and the least significant change (LSC) was 0.79% [ The analyses were performed using SPSS 14 statistics package (SPSS, Chicago, IL, USA).The baseline characteristics had a skewed distribution and were analysed using non-parametric methods.Elevated anti-CCP levels were consistent and independent predictors of loss in cortical hand bone during the study period, with the odds ratios (95% confidence interval) 2.2 (1.0 to 4.5), 2.6 (1.1 to 6.2) and 4.9 (1.4 to 16.7) for the 1, 2, and 5-year follow-up periods, respectively.Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by synovitis and bone destruction.First, univariate linear regression analyses were performed with one, two and five-year change in BMD as dependent variables and the dichotomised soluble biomarkers as independent variables.

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